inforMED
MalfunctionNBC

PROBNP II, N-TERMINAL PRO B-TYPE NATRIURETIC PEPTIDE

Received Jul 26, 2018 · Event occurred May 19, 2018

Report 1823260-2018-02466 · MDR key 7721635

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Product code (NBC)
Manufacturer (Roche Diagnostics International Ltd.)
Model (NA)

Device

Generic name

Test,natriuretic Peptide

Manufacturer

Roche Diagnostics

Model number

NA

Catalog number

04842464190

Lot number

31591400

Product problems

  • Low Test Results
  • Low Test Results

Patient

Not reported

  • No Consequences Or Impact To Patient
  • No Consequences Or Impact To Patient

Narrative

Additional Manufacturer Narrative

THE CUSTOMER PROVIDED SAMPLE WAS TESTED AND A PROBNP MUTATION COULD BE CONFIRMED. THE INVESTIGATION IS ONGOING.

Additional Manufacturer Narrative

THIS EVENT OCCURRED IN (B)(6).

Description of Event or Problem

THE CUSTOMER RECEIVED QUESTIONABLE LOW ELECSYS PROBNP II IMMUNOASSAY RESULTS FOR TWO PATIENTS WHICH DID NOT MATCH THE CLINICAL SYMPTOMS OF CHRONIC HEART FAILURE. SAMPLES FROM (B)(6) 2018 AND (B)(6) 2018 HAD A RESULT OF <5.00 PG/ML. THE RESULTS WERE REPORTED OUTSIDE OF THE LABORATORY AND WERE QUESTIONED. THERE WAS NO ALLEGATION OF AN ADVERSE EVENT. THE TYPE OF ROCHE ANALYZER USED WAS REQUESTED BUT WAS NOT PROVIDED. THE SAMPLE FROM (B)(6) 2018 WAS SUBMITTED FOR INVESTIGATION AND THE RESULT FROM A COBAS E 411 IMMUNOASSAY ANALYZER WAS <5.00 PG/ML.

Additional Manufacturer Narrative

IT WAS DETERMINED THE CONFIRMED MUTATION IS EXTREMELY RARE AND SO FAR HAS ONLY FOUND IN JAPANESE POPULATIONS. PRODUCT LABELING FOR THE ASSAY DOCUMENTS THIS LIMITATION.