inforMED
MalfunctionCIT

ASPARTATE AMINOTRANSFERASE ACC. TO IFCC WITHOUT PYRIDOXAL PHOSPHATE ACTIVATION

Received Jun 16, 2015 · Event occurred Apr 6, 2015

Report 1823260-2015-03640 · MDR key 4846629

Device

Generic name

Nadh Oxidation/nad Reduction, Ast/sgot

Manufacturer

Roche Diagnostics

Model number

NA

Catalog number

20764949322

Lot number

61168

Product problems

  • Incorrect Or Inadequate Test Results

Patient

025 YR

  • No Consequences Or Impact To Patient

Narrative

Description of Event or Problem

THE CUSTOMER RECEIVED QUESTIONABLE ASPARTATE AMINOTRANSFERASE (AST) RESULTS FOR ONE PATIENT FROM A COBAS C501. (B)(6) 2015: 311 U/L 02/21/2015: 551 U/L 10/09/2013: 291 U/L IT WAS UNCERTAIN IF THESE RESULTS WERE GENERATED FROM THE SAME PATIENT SAMPLE. WITH THE SAMPLE THAT GENERATED THE RESULT OF 311 U/L, THE CUSTOMER PERFORMED PRECIPITATION WITH PEG5000: SAMPLE WITH PEG5000 25% IN PBS (1)- <10 U/L SAMPLE WITH PEG5000 25% IN PBS (2)- <10 U/L %PPA 96.8% (PPA REF 18-53 %). THE RESULTS WERE REPORTED OUTSIDE THE LABORATORY. THE PATIENT WAS NOT ADVERSELY AFFECTED. THE CUSTOMER SUSPECTED THE PRESENCE OF A MACROENZYME, ONE COMPLEXED WITH AN IMMUNOGLOBULIN AND AST.

Additional Manufacturer Narrative

A SPECIFIC ROOT CAUSE COULD NOT BE IDENTIFIED. BASED ON THE PROVIDED DATA, IT WAS DETERMINED THE TEST MEASURED THE CORRECT AMOUNT OF AST IN THE PATIENT SAMPLE WHICH WAS ELEVATED DUE TO POSSIBLE MACRO ENZYMES.

Additional Manufacturer Narrative

THIS EVENT OCCURRED IN (B)(6).