inforMED
MalfunctionLBR

LDL-CHOLESTEROL GEN.3

Received Aug 14, 2025 · Event occurred Jul 24, 2025

Report 1823260-2025-02487 · MDR key 22805848

Device

Generic name

System, Test, Low Density, Lipoprotein

Manufacturer

Roche Diagnostics

Catalog number

07005717190

Lot number

ASKU

Product problems

  • Chemical Problem
  • Non Reproducible Results
  • Chemical Problem
  • Non Reproducible Results

Patient

NA · Unknown

  • No Clinical Signs, Symptoms or Conditions
  • No Clinical Signs, Symptoms or Conditions

Narrative

Description of Event or Problem

THERE WAS AN ALLEGATION OF QUESTIONABLE LDL-CHOLESTEROL GEN.3 RESULTS FOR ONE PATIENT SAMPLE TESTED ON A COBAS 8000 COBAS C 502 MODULE WHEN COMPARED TO THE BECKMAN COULTER AU5800 MODULE. THE INITIAL RESULT ON THE C 502 WAS 0.95 MMOL/L. THE REPEAT RESULT ON THE AU5800 WAS 2.92 MMOL/L.

Additional Manufacturer Narrative

THE SERIAL NUMBER OF THE ANALYZER WAS (B)(6). THE INVESTIGATION IS ONGOING.

Additional Manufacturer Narrative

THE CUSTOMER INDICATED THAT CALIBRATION AND QUALITY CONTROL OVER TIME WERE WITHIN THE EXPECTED RANGE. THE INVESTIGATION DETERMINED THE ISSUE WAS LIKELY DUE TO THE PRESENCE OF A BIOLOGICAL INTERFERENCE OF THE ANALYTE. PER THE METHOD SHEET, "ABNORMAL LIVER FUNCTION AFFECTS LIPID METABOLISM; CONSEQUENTLY HDL AND LDL RESULTS ARE OF LIMITED DIAGNOSTIC VALUE. IN SOME PATIENTS WITH ABNORMAL LIVER FUNCTION, THE LDL-CHOLESTEROL RESULT IS SIGNIFICANTLY NEGATIVELY BIASED VERSUS BETA QUANTIFICATION RESULT." NO PRODUCT PROBLEM WAS IDENTIFIED.