inforMED
MalfunctionCKA

ALANINE AMINOTRANSFERASE ACC. TO IFCC WITHOUT PYRIDOXAL PHOSPHATE ACTIVATION

Received May 30, 2025 · Event occurred Apr 30, 2025

Report 1823260-2025-01674 · MDR key 22116026

Device

Generic name

Nadh Oxidation/nad Reduction, Alt/sgpt

Manufacturer

Roche Diagnostics

Catalog number

20764957322

Lot number

ASKU

Product problems

  • Incorrect, Inadequate or Imprecise Result or Readings
  • Incorrect, Inadequate or Imprecise Result or Readings

Patient

81 YR · Male

  • No Clinical Signs, Symptoms or Conditions
  • No Clinical Signs, Symptoms or Conditions

Narrative

Additional Manufacturer Narrative

A GENERAL REAGENT ISSUE IS UNLIKELY BECAUSE QC AND CALIBRATION WERE IN RANGE AT THE TIME OF THE EVENT. THE INVESTIGATION WAS UNABLE TO DETERMINE AN EXACT ROOT CAUSE, AND NO PRODUCT ISSUE WAS FOUND.

Description of Event or Problem

THERE WAS AN ALLEGATION OF A QUESTIONABLE ALANINE AMINOTRANSFERASE ACC. TO IFCC WITHOUT PYRIDOXAL PHOSPHATE ACTIVATION RESULT FROM THE COBAS 6000 C501 MODULE, SUSPECTING A NEGATIVE INTERFERENCE. THE INITIAL RESULT WAS 67.3 U/L, ACCOMPANIED BY A DATA FLAG, WITH A REPEAT RESULT OF 97.6 U/L, ALSO ACCOMPANIED BY A DATA FLAG. AFTER THE SAMPLE WAS DILUTED, THE DATA FLAG DID NOT OCCUR, HOWEVER, THIS RESULT WAS NOT REPRODUCIBLE ON REPEAT TESTING ON DIFFERENT ANALYZERS.

Additional Manufacturer Narrative

THE COBAS 6000 C501 MODULE SERIAL NUMBER IS (B)(6). THE INVESTIGATION IS ONGOING.