inforMED
InjuryPLL

ORISE GEL

Received Dec 27, 2024 · Event occurred Dec 1, 2024

Report 3005099803-2024-06608 · MDR key 21028641

Device

Generic name

Submucosal Injection Agent

Product problems

  • Adverse Event Without Identified Device or Use Problem
  • Adverse Event Without Identified Device or Use Problem

Patient

NA · Unknown

  • Granuloma
  • Granuloma

Narrative

Description of Event or Problem

BOSTON SCIENTIFIC BECAME AWARE OF AN EVENT INVOLVING AN ORISE GEL THROUGH THE ARTICLE, GONE BUT NOT FORGOTTEN: EXPANDING THE SPECTRUM OF ORISE (SUBMUCOSAL LIFTING AGENT) ASSOCIATED DIAGNOSTIC PITFALLS AND COMPLICATIONS, BY POOJA DHORAJIYA, ET AL. PER THE ARTICLE, ALL SPECIMENS SHOWING LIFTING AGENT GRANULOMATA (LAGS) ASSOCIATED WITH THE USE OF ORISE WERE IDENTIFIED. 34 CASES (28 RESECTIONS AND 6 REPEAT ENDOSCOPIC MUCOSAL RESECTION SPECIMENS) SHOWED LAG. IN 64.2% OF CASES, A MASS LESION WAS SEEN GROSSLY BUT NO MALIGNANCY WAS IDENTIFIED MICROSCOPICALLY. LAGS WERE SEEN UP TO 10 MONTHS AFTER THE USE OF ORISE IN THE PRIOR ENDOSCOPIC PROCEDURE.

Additional Manufacturer Narrative

BLOCK B3: APPROXIMATED BASED ON THE DATE THE MANUFACTURER BECAME AWARE OF THE EVENT. BLOCK H6: IMDRF IMPACT CODE F19 CAPTURES THE REPORTABLE EVENT OF SURGICAL INTERVENTION. IMDRF IMPACT CODE F2202 CAPTURES THE REPORTABLE EVENT OF ENDOSCOPIC PROCEDURE. BLOCK G2: DHORAJIYA P, ET AL. J CLIN PATHOL 2024;0:1-5. 10.1136/JCP-2024-209419.