inforMED
MalfunctionOCC

COBAS® INFLUENZA A/B & RSV NUCLEIC ACID TEST FOR USE ON THE COBAS® LIAT® SYSTEM

Received Oct 30, 2024 · Event occurred Oct 7, 2024

Report 2243471-2024-03134 · MDR key 20569037

Device

Generic name

Respiratory Virus Panel Nucleic Acid Assay System

Catalog number

08160104190

Lot number

ASKU

Product problems

  • False Positive Result
  • False Positive Result

Patient

NA · Unknown

  • No Clinical Signs, Symptoms or Conditions
  • No Clinical Signs, Symptoms or Conditions

Narrative

Additional Manufacturer Narrative

A REVIEW OF THE DATA SHOWED THAT THE ALLEGED SAMPLE INITIALLY GENERATED A POSITIVE RESULT FOR THE INFLUENZA A AND RSV TARGETS. THE REPEAT RUN WAS PERFORMED WITH A DIFFERENT INSTRUMENT USING THE COBAS SARS-COV-2 & INFLUENZA A/B TEST WHICH GENERATED NEGATIVE RESULTS FOR ALL 3 TARGETS. THE DATA REVIEW IDENTIFIED 2 MORE SAMPLES GENERATING THE SAME DISCREPANCY. NOTE, SAMPLE 3 WAS ALSO REPEATED ON THE COBAS® INFLUENZA A/B & RSV ASSAY WHICH GENERATED NEGATIVE RESULTS FOR ALL 3 TARGETS. THE INVESTIGATION IS COMPLETE AND REVEALED THAT MICROLEAKS FROM POSITIVE SAMPLES COULD POTENTIALLY INTRODUCE INTERNAL CONTAMINATES. THE FALSE POSITIVE RATES OBSERVED ARE WITHIN THE CLAIMS OF THE IFU.

Additional Manufacturer Narrative

THE SERIAL NUMBER OF THE ANALYZER IS (B)(6). INVESTIGATION IS ONGOING.

Description of Event or Problem

THERE WAS AN ALLEGATION OF QUESTIONABLE RESULTS FOR A SINGLE PATIENT SAMPLE TESTED ON THE COBAS® INFLUENZA A/B & RSV NUCLEIC ACID TEST FOR USE ON THE COBAS® LIAT® SYSTEM. THE ALLEGED SAMPLE INITIALLY GENERATED A POSITIVE RESULT ON THE COBAS® LIAT ANALYZER. THE RETESTED SAMPLE GENERATED A NEGATIVE RESULT ON A DIFFERENT INSTRUMENT.