inforMED
MalfunctionQOF

BD RESPIRATORY VIRAL PANEL FOR BD MAX¿ SYSTEM

Received Sep 26, 2024 · Event occurred Aug 27, 2024

Report 3007420875-2024-00091 · MDR key 20312772

Device

Generic name

Multiple-genus Respiratory Virus Nucleic Acid Ivd, Kit, Nucleic Acid Technique

Catalog number

445215

Lot number

3353169

Product problems

  • False Negative Result
  • False Negative Result

Patient

NA · Unknown

  • No Clinical Signs, Symptoms or Conditions
  • No Clinical Signs, Symptoms or Conditions

Narrative

Additional Manufacturer Narrative

D2: ADDITIONAL MEDICAL DEVICE TYPES: QQX. A DEVICE EVALUATION IS ANTICIPATED BUT HAS NOT YET BEGUN. UPON COMPLETION OF THE INVESTIGATION, A SUPPLEMENTAL REPORT WILL BE FILED.

Description of Event or Problem

REPORT 1 OF 3: IT WAS REPORTED THAT DURING USE OF THE BD MAX¿ RESPIRATORY VIRAL PANEL, A FALSE NEGATIVE RSV PATIENT RESULT WAS OBTAINED. THE CUSTOMER RE-RAN SAMPLE ON RSV RAPID TEST AND RESULT WAS POSITIVE. THERE WAS NO REPORT OF PATIENT IMPACT.

Description of Event or Problem

REPORT 1 OF 3: IT WAS REPORTED THAT DURING USE OF THE BD MAX¿ RESPIRATORY VIRAL PANEL, A FALSE NEGATIVE RSV PATIENT RESULT WAS OBTAINED. THE CUSTOMER RE-RAN SAMPLE ON RSV RAPID TEST AND RESULT WAS POSITIVE. THERE WAS NO REPORT OF PATIENT IMPACT.

Additional Manufacturer Narrative

INVESTIGATION SUMMARY: THE COMPLAINT INVESTIGATION FOR DISCREPANT RESULTS WHEN USING THE BD MAX¿ RESPIRATORY VIRAL PANEL ASSAY (REF. 445215) FROM LOT: 3353169 WAS PERFORMED BY THE REVIEW OF MANUFACTURING RECORDS, REVIEW OF CUSTOMER¿S DATA, REVIEW OF CUSTOMER¿S PICTURES, RETAIN MATERIAL TESTING AND BY THE COMPLAINT¿S HISTORY REVIEW. CUSTOMER REPORTED OBTAINING 2 RSV AND 1 COVID POSITIVE RESULTS WHEN USING AG RAPID TESTS THAT REPEATED NEGATIVE WHEN USING THE BD MAX¿ RESPIRATORY VIRAL PANEL KIT LOT: 3353169. REVIEW OF THE MANUFACTURING RECORDS OF BD MAX¿ RESPIRATORY VIRAL PANEL ASSAY INDICATED THAT LOT: 3353169 WAS MANUFACTURED ACCORDING TO SPECIFICATIONS AND MET PERFORMANCE REQUIREMENTS. CUSTOMER PROVIDED DATABASE FROM BD MAX INSTRUMENT CT0448 AND PICTURES OF THREE AG RAPID TESTS FOR INVESTIGATION. SINCE NO ADDITIONAL INFORMATION WAS PROVIDED TO HELP IDENTIFY DISCREPANT SAMPLES, BD CANNOT CONFIRM WHICH SAMPLES ARE INVOLVED IN THE ISSUE. HOWEVER, DATABASE ANALYSIS SHOWS THAT THERE ARE ONLY TWO SAMPLES THAT WERE REPEATED AND OBTAINED NEGATIVE RESULTS FOR ALL TARGETS, IN BOTH THE INITIAL AND REPEAT TESTS (RUN 2242; POSITIONS A2 AND A3, AND 2243; A5 AND A6) HENCE THEY WERE SUSPECTED TO BE THE DISCREPANT ONES. IN BOTH SAMPLES, NO AMPLIFICATION WAS VISIBLE FOR ANY TARGET EXCEPT FOR THE INTERNAL CONTROL, AS EXPECTED FOR A NEGATIVE SAMPLE. A POSITIVE RESULT FOR THE AG RAPID TESTS MEANS THAT THE PATIENT WAS PREVIOUSLY INFECTED WITH THE VIRUS, DEVELOPED ANTIGENS AGAINST THE VIRUS BUT IT IS POSSIBLE THAT THERE ARE NO REMAINING VIRAL PARTICLES IN THE PATIENT. AS PER THE INSTRUCTION FOR USE (IFU) DOCUMENT, THE INTENDED USE OF THE BD MAX¿ RESPIRATORY VIRAL PANEL IS FOR PATIENTS DISPLAYING SYMPTOMS OF A RESPIRATORY VIRAL INFECTION. THE RETAIN MATERIAL OF BD MAX¿ RESPIRATORY VIRAL PANEL FROM LOT: 3353169 WAS TESTED AND THE RESULTS WERE AS EXPECTED. THERE IS NO INDICATION OF A REAGENT ISSUE BASED ON THE ANALYSIS OF THE COMPLAINTS RECEIVED FOR DISCREPANT RESULTS ON THE BD MAX¿ RESPIRATORY VIRAL PANEL ASSAY LOT: 3353169. THE ROOT CAUSE WAS NOT IDENTIFIED. BD CANNOT CONFIRM THE COMPLAINT BASED ON THE INVESTIGATION THAT WAS PERFORMED. BD DID NOT INITIATE A CORRECTIVE AND PREVENTIVE ACTION SINCE NO NEW HAZARD OR TRENDS WAS IDENTIFIED. BD QUALITY WILL CONTINUE TO MONITOR FOR TRENDS.