inforMED
MalfunctionJHR

ELECSYS IGE II IMMUNOASSAY

Received Apr 12, 2023 · Event occurred Mar 14, 2023

Report 1823260-2023-01238 · MDR key 16727964

Device

Generic name

Immunoglobulin E Assay

Manufacturer

Roche Diagnostics

Model number

IGE II

Catalog number

04827031214

Lot number

619033

Product problems

  • Low Test Results
  • Non Reproducible Results
  • Low Test Results
  • Non Reproducible Results

Patient

52 YR · Male

  • No Clinical Signs, Symptoms or Conditions
  • No Clinical Signs, Symptoms or Conditions

Narrative

Additional Manufacturer Narrative

THE CUSTOMER DID NOT USE RACK/DISK ADAPTERS FOR THE 13MM TUBES. PRODUCT LABELING STATES "INSERTING A ROCHE RACK CUP ADAPTER INTO A RACK - USE ROCHE RACK CUP ADAPTERS TO IMPROVE THE ALIGNMENT OF 13 MM TUBES. WARNING ! INCORRECT RESULTS AND ERRORS DUE TO MISALIGNED SAMPLE TUBES NOT USING A ROCHE RACK CUP ADAPTER WITH 13 MM TUBES OR INCORRECT USE OF A ROCHE RACK CUP ADAPTER MAY CAUSE INCORRECT RESULTS OR ERRORS. R ALWAYS USE ROCHE RACK CUP ADAPTERS WITH 13 MM TUBES. ENSURE THAT SAMPLE TUBES ARE STRAIGHT." THE CLOTTING TIME WAS 7-10 MINUTES. THE MINIMUM CLOTTING TIME FOR MOST TUBE MANUFACTURERS IS 30 MINUTES. THE ALARM TRACE ON 14-MAR-2023 SHOWED "ASSAY REAGENT HOVERING (LIQUID LEVEL MISDETECTED DUE TO STATIC ELECTRICITY OR FILM)". THIS INDICATES THAT THERE MIGHT BE FILM PRESENT ON THE REAGENT. THE INVESTIGATION DID NOT IDENTIFY A REAGENT PROBLEM. BASED ON THE INFORMATION PROVIDED, THE CAUSE OF THE EVENT COULD NOT BE DETERMINED.

Description of Event or Problem

THERE WAS AN ALLEGATION OF QUESTIONABLE ELECSYS IGE II IMMUNOASSAY RESULTS FOR 2 PATIENT SAMPLES ON A COBAS E 411 IMMUNOASSAY ANALYZER. ON (B)(6) 2023, PATIENT 1 HAD AN INITIAL IGE RESULT OF 1.6 IU/ML. THE REPEAT RESULT WAS 93.0 IU/ML. PATIENT 2 HAD AN INITIAL IGE RESULT OF 1.5 IU/ML. THE REPEAT RESULT WAS 141.2 IU/ML. THE PATIENT SAMPLES WERE SENT FOR INVESTIGATION. ON (B)(6) 2023, THE PATIENTS' SAMPLES WERE TESTED AT AN INVESTIGATIONAL LABORATORY. FOR PATIENT 1, THE INITIAL UNDILUTED RESULTS WERE 92.72 IU/ML, 94.54 IU/ML, AND 91.08 IU/ML. A 1:2 DILUTION WAS MADE AND THE RESULT WAS 83.48 IU/ML. A 1:5 DILUTION WAS MADE AND THE RESULT WAS 75.90 IU/ML. A 1:10 DILUTION WAS MADE AND THE RESULT WAS 77.42 IU/ML. FOR PATIENT 2, THE INITIAL UNDILUTED RESULTS WERE 137.8 IU/ML, 135.1 IU/ML, AND 137.2 IU/ML. A 1:2 DILUTION WAS MADE AND THE RESULT WAS 130.6 IU/ML. A 1:5 DILUTION WAS MADE AND THE RESULT WAS 115.9 IU/ML. A 1:10 DILUTION WAS MADE AND THE RESULT WAS 115.8 IU/ML. NO QUESTIONABLE RESULTS WERE REPORTED OUTSIDE OF THE LABORATORY. THE ANALYZER SERIAL NUMBER IS (B)(4).

Additional Manufacturer Narrative

THE INVESTIGATION IS ONGOING.