inforMED

FREE LITE HUMAN LAMBDA FREE KIT-OLYMPUS AU SERIES

Received Sep 30, 2008 · Event occurred Sep 10, 2008

Report 1209263 · MDR key 1209263

Device

Generic name

Reagent, Monoclonal

Model number

*

Catalog number

*

Lot number

LOT# 257764A

Product problems

  • Incorrect Or Inadequate Test Results

Patient

*

  • Unknown (for use when the patient's condition is not known)

Narrative

Description of Event or Problem

UPON RECEIPT OF A NEW LOT OF REAGENT (THE BINDING SITE LTD., SAN DIEGO, CA, LOT #257764A)FOR SERUM FREE LIGHT CHAIN LAMBDA, OUR METHOD VALIDATION NOTED A SHIFT BETWEEN LOTS >40%. FREE LAMBDA CHAIN RESULTS DISPLAYED CLINICALLY SIGNIFICANT DIFFERENCES IN 4 OUT OF 5 PATIENTS AS WELL AS KAPPA/LAMBDA RATIO CHANGES IN 3 OUT OF 5 PATIENTS. ====================== MANUFACTURER RESPONSE FOR SPECIFIC LOT # OF REAGENT, FREE LITE HUMAN LAMBDA FREE KIT-OLYMPUS AU SERIES======================IN AN ATTEMPT TO RESOLVE THE PROBLEM, THE DISCREPANT SAMPLES WERE ALSO ASSAYED BY THE MANUFACTURER WHO REPORTED THE SAME DISCREPANCIES, BUT OFFERED NO SOLUTION TO THE PROBLEM. WE SUGGESTED THAT THE MANUFACTURER INFORM OTHER REAGENT USERS OF THE PROBLEM. MANUFACTURER INDICATED THAT THE PROBLEM WAS UNIQUE TO OUR LAB.