inforMED
MalfunctionGSH

BD DIFCO; LISTERIA O ANTISERUM POLY SEROTYPES 1, 4

Received Mar 2, 2021 · Event occurred Feb 3, 2021

Report 1025402-2021-00002 · MDR key 11401353

Device

Generic name

Antisera, All Types, Listeria Monocytogenes

Model number

223021

Catalog number

223021

Lot number

9200273

Product problems

  • Incorrect, Inadequate or Imprecise Result or Readings
  • Incorrect, Inadequate or Imprecise Result or Readings

Patient

Not reported

  • No Clinical Signs, Symptoms or Conditions
  • No Clinical Signs, Symptoms or Conditions

Narrative

Additional Manufacturer Narrative

H6: INVESTIGATION SUMMARY: RETURN SAMPLES DO NOT APPLY; THIS COMPLAINT WAS INITIATED BASED ON INTERNAL TESTING OF THE PRODUCT, PERFORMED BY BD. TO INVESTIGATE THE COMPLAINT, A RETAINED SAMPLE OF THE LOT WAS TESTED, PER THE PRODUCT PACKAGE INSERT, WITH MULTIPLE LOTS OF LISTERIA O ANTIGEN TYPE 1 (SLIDE), ONE OF THE QC ANTIGENS FOR THE PRODUCT, ALSO MANUFACTURED AT BD GRAYSON. THE RETAINED VIAL OF ANTISERUM DEMONSTRATED NEGATIVE REACTIONS AT 2 MINUTES WITH THESE QC ANTIGEN LOTS. TO FURTHER INVESTIGATE THE ISSUE, THE ANTISERUM WAS ALSO TESTED WITH SEVERAL CULTURES REPRESENTING LISTERIA MONOCYTOGENES TYPE 1 (TYPE 1/2A AND TYPE 1/2B CULTURE STRAINS WERE USED IN THIS TESTING). REACTIONS OBSERVED WITH THE CULTURES TESTED RANGED FROM NEGATIVE TO 3+. THE COMPLAINT WAS CONFIRMED BASED ON THESE RESULTS. THE BATCH HISTORY RECORD FOR THE LOT WAS REVIEWED AND FOUND SATISFACTORY; NO QUALITY NOTIFICATIONS WERE ISSUED FOR THIS BATCH. THE COMPLAINT WAS CONFIRMED. CAPA INITIATION DETERMINATION (CID) (B)(4) WAS COMPLETED ON 02/08/2021. BASED ON THE CID, THE TEAM DECISION WAS TO INITIATE A CAPA. H3 OTHER TEXT : SEE H10.

Description of Event or Problem

IT WAS REPORTED DURING BENCH TESTING WITH BD DIFCO¿; LISTERIA O ANTISERUM POLY SEROTYPES 1, 4 A WEAK REACTION WAS OBSERVED WITH 4 VIALS. RESULTS WERE NOT REPORTED THERE WAS NO REPORT OF PATIENT IMPACT.

Additional Manufacturer Narrative

A DEVICE EVALUATION IS ANTICIPATED, BUT HAS NOT YET BEGUN. UPON COMPLETION OF THE INVESTIGATION, A SUPPLEMENTAL REPORT WILL BE FILED.

Description of Event or Problem

IT WAS REPORTED DURING BENCH TESTING WITH BD DIFCO¿; LISTERIA O ANTISERUM POLY SEROTYPES 1, 4 A WEAK REACTION WAS OBSERVED WITH 4 VIALS. RESULTS WERE NOT REPORTED THERE WAS NO REPORT OF PATIENT IMPACT.